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Gelatin has been the choice for immediate release formulations for more than 100 years. It opens quickly and is completely dissolved in 20 to 30 minutes. Vcaps® Plus capsules, made from HPMC, need a hydration period in order to pull water into the matrix to allow disintegration to begin. Gelatin, already containing 12-16% water, does not need that same hydration period. The initial lag of 3 to 5 minutes is a phenomenon that occurs in all commercially available HPMC capsules, either first or second generation. But Vcaps Plus capsules still meet the USP standards for an immediate release formulation.