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There are 5 total entries

Capsugel
Amorphous Solid Dispersions Using Hot-Melt Extrusion Technology

Amorphous solid dispersions have enabled progression of many low aqueous solubility compounds
by providing enhanced oral bioavailability from the modified drug form. While there are several
platform technologies and manufacturing techniques to produce amorphous solid dispersions,
hot-melt extrusion (HME) is continually explored as one of the lead approaches based on mature
process understanding, small process footprint, continuous operation, and readily scalable.
These attributes of the HME process trend toward more of a plug-and-play unit operation resulting
in relatively lower cost of goods to manufacture compared to other technologies, making it a more
appealing commercial process train.

Small-Scale Manufacture of Modified Release Coated Beads for Pre-clinical Drug Discovery Research
Small-Scale Manufacture of Modified Release Coated Beads for Pre-clinical Drug Discovery Research

Drug Discovery Research using preclinical animals requires broadly applicable small scale formulation methods for assessing at an early stage compounds and targets. The present work focuses on manufacture and performance of small scale modified release formulations using a custom built “micro” fluid-bed system capable of spray-coating nominally 0.5 to 1-g batches (approximately 100 mg API) of 60 μm diameter particles.

Impact of Polymer Composition and Properties on the Dissolution Characteristics of HPMCAS-Based SDDs
Impact of Polymer Composition and Properties on the Dissolution Characteristics of HPMCAS-Based SDDs

Drug Discovery Research using preclinical animals requires broadly applicable small scale formulation methods for assessing at an early stage compounds and targets. The present work focuses on manufacture and performance of small scale modified release formulations using a custom built “micro” fluid-bed system capable of spray-coating nominally 0.5 to 1-g batches (approximately 100 mg API) of 60 μm diameter particles.

Capsugel
Oral multiparticulate technologies

A broad range of formulation needs can be addressed with oral multiparticulate technologies available at Bend Research. Pellets, beads, microspheres, and mini-tablets with coated and/or matrix architectures can be formulated as immediate-release, modified-release (e.g., extended, delayed, pulsed), bioavailability-enhanced, and taste-masked drug product intermediates.  

Webinar - Rational Design of Modified Release Dosage Forms
Webinar - Rational Design of Modified Release Dosage Forms

This webinar will discuss the wide array of scalable dosage form technologies that are available as well as the matching technology strengths with API properties. The presenters will then discuss how you can bring all of the choices together through biological modeling.

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