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Proven applications for this versatile technology include delayed release, extended release, pulsatile release, and fixed dose combinations. We also utilize spray layered multiparticulates, and other modified release technologies, in conjunction with bioavailability enhancement technologies to optimize overall drug availability.
We use an array of fluid-bed equipment to produce high-yield, high-quality coatings and can produce spray-layered multiparticulates at the feasibility, laboratory, clinical and small commercial scales at batch sizes as small as 2 g. Fluid bed coaters, dryers and granulators at a range of scales enable clinical trial supply for phase I-III.
Capsugel Dosage Form Solutions has also developed osmotic-bursting multiparticulates with a barrier-coating option to approximate zero-order release.
Drug release is controlled primarily by manipulating coating type and weight. Advantages of this approach include: