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Bioavailability Enhancement Suite: Solid NanoCrystalline Dispersions (SNCDs)

For drugs with low solubility or bioavailability, Capsugel Dosage Form Solutions offers a wide range of formulation options and technologies that maximize the opportunity for development and commercial success of drug candidates.

Our solid nanocrystalline dispersions (SNCD) technology offers another formulation tool to enhance the bioavailability of low-solubility compounds.

SNCDs, which consist of drug crystals embedded in a polymer-rich matrix, are created by purposeful formation of submicron, high-energy crystals from amorphous dispersions. They can be formed through crystallization of the drug in a spray-dried dispersion (SDD) under controlled conditions (i.e., temperature and humidity) that favor high nucleation rates over crystal growth.

SNCDs have two important advantages:

Thus, it is possible to attain both good performance and good stability with SNCDs.

SNCD Process Overview:

Process of formin an SNCD

Transmission Electron Microscopy (TEM) analysis of an SNCD

Transmission Electron Microscopy (TEM) analysis of an SNCD

SNCDs are best used in cases where any of the following apply:

Through our SNCD work, we have demonstrated the following:

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