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Through the integration of Bend Research and Powdersize, we now have expanded capabilities in the space of particle size reduction to low micron or sub-micron levels for a variety of applications in pharmaceutical drug delivery. Stability, flowability, dissolution rate and bioavailability (BA) are all critical performance parameters impacted by size distribution of particles.
Micronization and nano-milling are used routinely in many applications in solid oral and other dosage forms:
Our Powdersize Division is a full service provider of particle size reduction and particle size control / classification technologies. With over 20 years of manufacturing experience, we routinely develop robust processes at any scale of development through commercialization:
High containment capability is in place in support of particle size reduction of highly potent and cytotoxic compounds. A range of mechanical and jet milling capabilities are available within an isolator designed to meet containment levels down to 1µg/m3 at scales from 2-100kg batch sizes.
Nano-milling capability is also in place through a Netzsch DeltaVita® media mill. This equipment provides additional size reduction to nano-scale, and produces q development and production quantities. The DeltaVita uses proprietary wet grinding technology to produce batch sizes ranging from 15mL to 300mL, with appropriate processing parameters and a suitably formulated solution to stabilize the sub-micronparticles.