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Osmotic Tablet Technologies

For clients whose projects require or can benefit from zero-order or slow extended-release profiles, Capsugel Dosage Form Solutions uses two osmotic tablet technologies — osmotic asymmetric-membrane technology (AMT) and osmotic swellable-core technology (SCT). Both of these technologies provide steady-state, zero order release drug release driven by osmotic/hydrostatic pressure.
Osmotic Tablet Technologies

Osmotic Asymetric-Membrane Technology (AMT)

Osmotic Asymmetric-Membrane Technology (AMT)

Osmotic Swellable Core Technology (SCT)Osmotic Swellable Core Technology (SCT)

Release profiles are generally independent of pH and stirring rate. The attributes of these technologies minimize patient-to-patient variability and allow accurate prediction of in vivo performance from in vitro dissolution test results. A wide range of release rates is possible by varying the size of the laser-drilled hole, the coating application, and composition of the sweller layer, for instance.  

Matrix bilayer tablets offer a viable alternative slow extended release approach to osmotic technology for some clients, especially for fixed-dose combinations.

Capsugel Dosage Form Solutions has techniques and experience in formulating and scaling technologies from feasibility scale (<10 tablets/batch), laboratory (0.1 to 4 kg), pilot (4 to 40 kg), and production scale (250 kg). We have in-house capabilities to manufacture clinical supplies for studies from Phase 1 through Phase 3 and have established partners for commercial-scale manufacture. We also offer a range of specially designed laser drills for osmotic tablets for development work, as well as for clinical trial manufacture using current Good Manufacturing Practice (cGMP) conditions.

Additional Resources

Osmotic Tablet Technologies


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